Drink Less.
Weigh Less. Transform Your Life.
The only program that treats the craving behind both the drinking and the weight — at the same time. Semaglutide works on the dopamine reward system that drives both. One medication. One structured monthly protocol. Two complete transformations.
This isn't about willpower. Alcohol cravings are driven by brain chemistry — not character. Semaglutide changes that chemistry. You don't have to fight it alone anymore.
The Real Problem
You've Tried to Cut Back Before.
Your Brain Kept Pulling You Back.
Alcohol hijacks the brain's reward system. Every drink reinforces the neural pathway that says "do it again." Willpower, motivation, and good intentions are no match for a neurological loop that's been running for years.
That's not a character flaw. That's biology. And biology can be changed — with the right medication.
Semaglutide works on the same dopamine reward pathways that drive alcohol cravings. When those pathways quiet down, the urge to drink quiets down with them. Patients describe it as simply not wanting alcohol the way they used to.
The Science Is In.
Semaglutide Works.
The most widely cited clinical trial on GLP-1s and alcohol was published in JAMA Psychiatry in February 2025 — one of the most respected medical journals in the world.
Once-Weekly Semaglutide in Adults With Alcohol Use Disorder
Hendershot CS et al. · JAMA Psychiatry · February 12, 2025 · Randomized Clinical Trial
This landmark Phase 2 randomized, placebo-controlled trial — led by researchers at the University of Southern California — was the first prospective clinical trial to test semaglutide specifically in adults with alcohol use disorder. The results were striking.
Large effect size
Reduction in heavy drinking days (d > 0.80)
Significantly reduced
Weekly alcohol craving (P = .01)
−5% body weight
Average weight loss during the study
Exceeded naltrexone
Effect sizes surpass FDA-approved AUD medications
Low-dose only
Results at 0.25–0.5 mg/wk — far below weight-loss doses
Fewer drinks/day
Significant reduction in drinks per drinking day (P = .04)
"Effect sizes for heavy drinking days and drinks per drinking day reached the large range (d > 0.80) at the 0.5 mg/week dose... By comparison, approved (and effective) AUD medications, including naltrexone, generally show small effect sizes."
— Hendershot et al., JAMA Psychiatry, 2025 Feb 12;82(4):395–405. doi:10.1001/jamapsychiatry.2024.4789
This program is based on emerging clinical evidence. Individual results vary. Our providers will evaluate your specific situation and goals.
What You Can Expect
One Medication. Two Transformations.
Semaglutide addresses both the craving that keeps you drinking and the weight that's been building because of it.
Alcohol Cravings Dramatically Reduced
Semaglutide works on the same reward pathways that drive alcohol cravings — quieting the urge to drink at the neurological level.
Lose Weight at the Same Time
GLP-1s are the most effective weight loss medications ever developed. Patients in clinical trials lost an average of 5% body weight even at low doses.
Mental Clarity Returns
As alcohol consumption drops and metabolic health improves, patients consistently report sharper thinking, better sleep, and improved mood.
Cardiovascular Protection
Semaglutide has demonstrated cardiovascular benefits in major clinical trials — reducing risk of heart attack and stroke while you reduce your drinking.
More Energy, Less Inflammation
Alcohol is one of the most inflammatory substances you can put in your body. Reducing intake — and losing weight — dramatically lowers systemic inflammation.
No Willpower Required
This isn't about white-knuckling it. Semaglutide changes the biology of craving. Patients describe simply not wanting alcohol the way they used to.
Simple, Transparent Pricing
Everything Included.
$249 a Month.
No hidden fees. No separate pharmacy bill. No surprise charges. One flat monthly price covers your provider visits, your prescription, and your medication — shipped to your door.
Compare to $400–$800/month on alcohol + the health costs that come with it.
Most heavy drinkers spend $400–$800 a month on alcohol alone.
Add in lost productivity, healthcare costs, and the weight-related health expenses — and the real number is often much higher. See exactly what alcohol is costing you, and what you'd save with this program.
The Dual Transformation Protocol™
How the Protocol Works
Unlike every other semaglutide provider, we track two outcomes every month — not just your weight. Your provider sets written drink reduction goals alongside weight goals, and you receive a monthly Dual Transformation Summary showing progress on both.
Qualify & Get Your Prescription
Complete our short BMI and safety screener, meet your provider online within 48 hours, and receive your semaglutide prescription. No office visit. No waiting room.
Set Your Dual Transformation Goals
Your provider sets two written targets for your first 30 days: a specific drink reduction goal and a weight loss goal. These become your personal Dual Transformation baseline.
The Medication Does the Heavy Lifting
Semaglutide begins quieting the dopamine reward loop that drives both alcohol cravings and overeating. Most patients notice a significant shift in the urge to drink within the first 2–4 weeks.
Monthly Protocol Check-In
Every 30 days, your provider reviews both your drink reduction and weight progress, updates your written goals, and adjusts your dose. You receive a Dual Transformation Summary showing exactly how far you’ve come on both measures.
Track Your Transformation Score
Each month you get a single Transformation Score — a combined measure of drinks reduced and pounds lost. Patients who see both numbers moving together report the strongest motivation to keep going.
Two Numbers. One Story.
Every month, your provider sends you a Dual Transformation Summary — a side-by-side view of your two most important health numbers. No other semaglutide provider tracks both.
Patient Example
Month 3 Summary
Drinks Per Week
Starting point
18 drinks/wk
↓ Currently at 3 drinks/wk
Body Weight
Starting weight
224 lbs
↓ Currently 9.5 lbs lighter
This is a representative example. Individual results vary. Your provider sets goals based on your specific health profile.
No other semaglutide provider tracks both outcomes.
Every other telehealth clinic prescribes semaglutide for weight loss and calls it done. We prescribe it for both transformations — and we hold ourselves accountable to both numbers every single month.
Why Choose MAT's Clinic
Why This Is Different From
Every Other Semaglutide Provider.
Hims, Ro, LifeMD, and hundreds of compounding pharmacies sell semaglutide for weight loss. They prescribe the molecule and move on. We are an addiction clinic — led by a board-certified addictionologist — that uses semaglutide to treat the craving behind both the drinking and the weight. That is a fundamentally different program.
Board-Certified Addictionologist — Not a GP
Dr. Dave Daigle is one of a small number of board-certified addictionologists in the country. Other providers send you a general practitioner. We send you a specialist who has spent 20+ years treating addiction.
The Dual Transformation Protocol™
Every other telehealth clinic tracks your weight. We track two numbers: drinks reduced and pounds lost. Your provider sets written goals for both every month and holds the program accountable to both.
Monthly Dual Transformation Summary
You receive a written summary every 30 days showing your progress on both outcomes. No other semaglutide provider does this. It creates accountability and compounds your motivation.
Start Within 48 Hours
No 6-week waitlists. No driving to a clinic. Most patients are seen within 48 hours of requesting an appointment.
Providers Who Understand Addiction
Our team has personal connections to addiction and recovery. We don't just treat the condition — we treat the person. That changes everything about how you're cared for.
$249/Month. Everything Included.
Consultation, prescription, dose adjustments, monthly check-ins, and your Dual Transformation Summary — all for $249/month. Most patients spend more than that on alcohol in a single week.
Common Questions
You Have Questions. We Have Answers.
You've Read Enough. Now Take the Step.
The Version of You That Doesn't Need Alcohol
Is Still In There.
A 5-minute intake form is all it takes to find out if you qualify. No commitment. No judgment. Just a board-certified provider who will meet you exactly where you are.
Monday–Friday, 8 am–5 pm CST · Same-day appointments available